All changes are in red.
| Airport | Lower Richland | 9/21/2018 Fri | 7:30 PM |
| Andrew Jakson | Buford | 9/21/2018 Fri | 7:30 PM |
| Aynor | St. James | Postponed | |
| Barnwell | Midland Valley | 9/21/2018 Fri | 7:30 PM |
| Battery Creek | Wade Hampton (H) | 9/21/2018 Fri | 7:30 PM |
| Berea | Southside | 9/21/2018 Fri | 7:30 PM |
| Blackville-Hilda | Wagener-Salley | 9/21/2018 Fri | 7:30 PM |
| Blythewood | Beaufort | 9/21/2018 Fri | 7:30 PM |
| Boiling Springs | Dorman | 9/21/2018 Fri | 7:30 PM |
| Brookland -Cayce | Newberry | 9/21/2018 Fri | 7:30 PM |
| Byrnes | Gaffney | 9/21/2018 Fri | 7:30 PM |
| Calhoun County | Bamberg-Ehrhardt | 9/21/2018 Fri | 7:30 PM |
| Cane Bay | R.B. Stall | 9/21/2018 Fri | 7:30 PM |
| Carolina Forest | Loris | Postponed | |
| Carvers Bay | Latta | Cancelled | |
| Central | Lewisville | 9/21/2018 Fri | 7:30 PM |
| Chapin | A C Flora | 9/21/2018 Fri | 7:30 PM |
| Chapman | Eastside | 9/21/2018 Fri | 7:30 PM |
| Chesnee | Blacksburg | 9/21/2018 Fri | 7:30 PM |
| Chester | Carolina Pride | 9/21/2018 Fri | 7:30 PM |
| Chesterfield | Lee Central | 9/22/2018 Sat | 7:00 PM |
| Clover | Irmo | 9/21/2018 Fri | 7:30 PM |
| Colleton County | Ridgeland-Hardeeville | 9/21/2018 Fri | 7:30 PM |
| Columbia | Pelion | 9/21/2018 Fri | 7:30 PM |
| Conway | Myrtle Beach | Cancelled | |
| Creek Bridge | Marion | Cancelled | |
| Crescent | Fox Creek | 9/21/2018 Fri | 7:30 PM |
| Dutch Fork | Northwestern | 9/21/2018 Fri | 7:30 PM |
| Eau Claire | Allendale-Fairfax | 9/21/2018 Fri | 7:30 PM |
| Edisto | C. A. Johnson | 9/21/2018 Fri | 7:30 PM |
| Emerald | TBA | 9/21/2018 Fri | 7:30 PM |
| Estill | Hunter-Kinard-Tyler | 9/21/2018 Fri | 7:30 PM |
| Fort Mill | York | 9/21/2018 Fri | 7:30 PM |
| Garrett | Academic Magnet | 9/21/2018 Fri | 7:30 PM |
| Georgetown | Socastee | Cancelled | |
| Gilbert | River Bluff | 9/21/2018 Fri | 7:30 PM |
| Goose Creek | Fort Dorchester | 9/21/2018 Fri | 7:30 PM |
| Great Falls | Ware Shoals | 9/21/2018 Fri | 7:30 PM |
| Green Sea-Floyds | McBee | TBA | |
| Greenwood | Laurens | 9/21/2018 Fri | 7:30 PM |
| Hartsville | Abbeville | Postponed | |
| Hemingway | C. E. Murray | 9/21/2018 Fri | 7:30 PM |
| Hillcrest | Spartanburg | 9/21/2018 Fri | 7:30 PM |
| Hilton Head | Christ Church | 9/21/2018 Fri | 7:30 PM |
| Indian Land | South Pointe | 9/21/2018 Fri | 7:30 PM |
| J L Mann | Easley | 9/21/2018 Fri | 7:30 PM |
| Johnsonville | Andrews | 9/21/2018 Fri | 7:30 PM |
| Kingstree | Hannah-Pamplico | 9/21/2018 Fri | 7:30 PM |
| Lake Marion | Cross | 9/21/2018 Fri | 7:30 PM |
| Lamar | Lake View | 10/5/2018 Fri | 7:30 PM |
| Landrum | West-Oak | 9/21/2018 Fri | 7:30 PM |
| Lexington | Spring Valley | 9/21/2018 Fri | 7:30 PM |
| Marlboro County | Dillon | Postponed | |
| Mauldin | Riverside | 9/21/2018 Fri | 7:30 PM |
| Military Magnet | Branchville | 9/21/2018 Fri | 7:30 PM |
| Mullins | East Clarendon | Postponed | |
| Ninety Six | Dixie | 9/21/2018 Fri | 7:30 PM |
| North | Denmark-Olar | 9/21/2018 Fri | 7:30 PM |
| North Charleston | Baptist Hill | 9/21/2018 Fri | 7:30 PM |
| Pendleton | Clinton | 9/21/2018 Fri | 7:30 PM |
| Philip Simmons | Whale Branch | 9/21/2018 Fri | 7:30 PM |
| Powdersville | Palmetto | 9/21/2018 Fri | 7:30 PM |
| Richland Northeast | Camden | 9/21/2018 Fri | 7:30 PM |
| Ridge Spring Montetta | Williston-Elko | 9/21/2018 Fri | 7:30 PM |
| Rock Hill | Lugoff-Elgin | 9/21/2018 Fri | 7:30 PM |
| Saluda | Southside Christian | 9/21/2018 Fri | 7:30 PM |
| Seneca | Belton-Honea Path | 9/21/2018 Fri | 7:30 PM |
| Silver Bluff | Swansea | 9/21/2018 Fri | 7:30 PM |
| South Florence | Darlington | TBA | |
| St. John’s | Waccamaw | 9/21/2018 Fri | 7:30 PM |
| Strom Thurmond | North Augusta | 9/21/2018 Fri | 7:30 PM |
| Summerville | Berkeley | 9/21/2018 Fri | 7:30 PM |
| Sumter | Bluffton | 9/21/2018 Fri | 7:30 PM |
| T. L. Hanna | Westside | 9/21/2018 Fri | 7:30 PM |
| Timberland | Hanahan | 9/21/2018 Fri | 7:30 PM |
| Timmonsville | Scott’s Branch | 9/21/2018 Fri | 7:30 PM |
| W J Keenan | Ridge View | 9/20/2018 Thu | 7:30 PM |
| Walhalla | Carolina Academy | 9/21/2018 Fri | 7:30 PM |
| Wando | Ashley Ridge | 9/21/2018 Fri | 7:30 PM |
| West Ashley | Stratford | 9/21/2018 Fri | 7:30 PM |
| Westwood | Fairfield Central | 9/21/2018 Fri | 7:30 PM |
| Whitmire | Bethune-Bowman | 9/21/2018 Fri | 7:30 PM |
| Wilson | West Florence | 9/21/2018 Fri | 7:30 PM |
| Woodland | Bishop England | 9/21/2018 Fri | 7:30 PM |
| Woodmont | Wade Hampton (G) | 9/21/2018 Fri | 7:30 PM |
| Wren | Broome | 9/21/2018 Fri | 7:30 PM |