| Date | Time | Home | Away | |||
| 9/19/19 Thur | 7:30 | South Florence | Marlboro County | |||
| 9/19/19 Thur | 7:00 | SCSDB | TBA | |||
| 9/20/19 Fri | 7:30 | Andrew Jackson | North Central | |||
| 9/20/19 Fri 9/20/19 Fri |
7:30 7:30 |
Andrews Aynor |
East Clarendon Green Sea-Floyds |
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| 9/20/19 Fri | 7:30 | Berea | Pickens | |||
| 9/20/19 Fri | 7:30 | Blacksburg | Catawba Ridge | |||
| 9/20/19 Fri | 7:30 | Blackville-Hilda | Denmark-Olar | |||
| 9/20/19 Fri | 7:30 | Blue Ridge | Travelers Rest | |||
| 9/20/19 Fri | 7:30 | Blythewood | Dutch Fork | |||
| 9/20/19 Fri | 7:30 | Boiling Springs | Riverside | |||
| 9/20/19 Fri | 7:30 | Broome | Eastside | |||
| 9/20/19 Fri | 7:30 | Burke | Charleston M&S | |||
| 9/20/19 Fri | 7:30 | Byrnes | Spartanburg | |||
| 9/20/19 Fri | 7:30 | C E Murray | Lake Marion | |||
| 9/20/19 Fri | 7:30 | Calhoun County | TBA | |||
| 9/20/19 Fri | 7:30 | Camden | West Florence | |||
| 9/20/19 Fri | 7:30 | Cane Bay | Summerville | |||
| 9/20/19 Fri | 7:30 | Carolina Forest | Myrtle Beach | |||
| 9/20/19 Fri | 7:30 | Carvers Bay | Mullins | |||
| 9/20/19 Fri | 7:30 | Central | Lee Central | |||
| 9/20/19 Fri | 7:30 | Chapin | Spring Valley | |||
| 9/20/19 Fri | 7:30 | Chapman | Woodruff | |||
| 9/20/19 Fri | 7:30 | Chesterfield | Buford | |||
| 9/20/19 Fri | 7:30 | Christ Church | Southside | |||
| 9/20/19 Fri | 7:30 | Columbia | Fox Creek | |||
| 9/20/19 Fri | 7:30 | Cross | Baptist Hill | |||
| 9/20/19 Fri | 7:30 | Daniel | Ridge View | |||
| 9/20/19 Fri | 7:30 | Darlington | Crestwood | |||
| 9/20/19 Fri | 7:30 | Dixie | Great Falls | |||
| 9/20/19 Fri | 7:30 | Dreher | Gilbert | |||
| 9/20/19 Fri | 7:30 | Easley | Westside | |||
| 9/20/19 Fri | 7:30 | Edisto | Bamberg-Ehrhardt | |||
| 9/20/19 Fri | 7:30 | Emerald | Strom Thurmond | |||
| 9/20/19 Fri | 7:30 | Estill | Williston-Elko | |||
| 9/20/19 Fri | 7:30 | Fairfield Central | Newberry | |||
| 9/20/19 Fri | 7:30 | Fort Dorchester | Berkeley | |||
| 9/20/19 Fri | 7:30 | Fort Mill | Lugoff-Elgin | |||
| 9/20/19 Fri | 7:30 | Georgetown | St. James | |||
| 9/20/19 Fri | 7:30 | Goose Creek | R B Stall | |||
| 9/20/19 Fri | 7:30 | Greenwood | Woodmont | |||
| 9/20/19 Fri | 7:30 | Greenville | South Pointe | |||
| 9/20/19 Fri | 7:30 | Hanahan | Philip Simmons | |||
| 9/20/19 Fri | 7:30 | Hartsville | Bluffton | |||
| 9/20/19 Fri | 7:30 | Hemingway | Lakewood | |||
| 9/20/19 Fri | 7:30 | Hillcrest | Dorman | |||
| 9/20/19 Fri | 7:30 | Hilton Head | Ridgeland-Hardeeville | |||
| 9/20/19 Fri | 7:30 | Hunter-Kinard-Tyler | Wagener-Salley | |||
| 9/20/19 Fri | 7:30 | Indian Land | Nation Ford | |||
| 9/20/19 Fri | 7:30 | J L Mann | T L Hanna | |||
| 9/20/19 Fri | 7:30 | James Island | Ashley Ridge | |||
| 9/20/19 Fri | 7:30 | Johnsonville | Hannah-Pamplico | |||
| 9/20/19 Fri | 7:30 | Keenan | Carolina Pride | |||
| 9/20/19 Fri | 7:30 | Kingstree | Latta | |||
| 9/20/19 Fri | 7:30 | Lamar | Cheraw | |||
| 9/20/19 Fri | 7:30 | Lancaster | Chester | |||
| 9/20/19 Fri | 7:30 | Landrum | Chesnee | |||
| 9/20/19 Fri | 7:30 | Lexington | Batesburg-Leesville | |||
| 9/20/19 Fri | 7:30 | Liberty | Carolina Academy | |||
| 9/20/19 Fri | 7:30 | Lower Richland | Airport | |||
| 9/20/19 Fri | 7:30 | Manning | Lake City | |||
| 9/20/19 Fri | 7:30 | Marion | Lake View | |||
| 9/20/19 Fri | 7:30 | Mauldin | Gaffney | |||
| 9/20/19 Fri | 7:30 | May River | Colleton County | |||
| 9/20/19 Fri | 7:30 | McCormick | Eau Claire | |||
| 9/20/19 Fri | 7:30 | Military Magnet | Scott’s Branch | |||
| 9/20/19 Fri | 7:30 | Ninety Six | Mid-Carolina | |||
| 9/20/19 Fri | 7:30 | North Charleston | Waccamaw | |||
| 9/20/19 Fri | 7:30 | North Myrtle Beach | Socastee | |||
| 9/20/19 Fri | 7:30 | North | Ridge Spring-Monetta | |||
| 9/20/19 Fri | 7:30 | Orangeburg-Wilkinson | Woodland | |||
| 9/20/19 Fri | 7:30 | Pelion | C A Johnson | |||
| 9/20/19 Fri | 7:30 | Pendleton | Belton-Honea Path | |||
| 9/20/19 Fri | 7:30 | Powdersville | Walhalla | |||
| 9/20/19 Fri | 7:30 | Richland Northeast | A C Flora | |||
| 9/20/19 Fri | 7:30 | River Bluff | Irmo | |||
| 9/20/19 Fri | 7:30 | Rock Hill | York | |||
| 9/20/19 Fri | 7:30 | Seneca | Palmetto | |||
| 9/20/19 Fri | 7:30 | Silver Bluff | Allendale-Fairfax | |||
| 9/20/19 Fri | 7:30 | South Aiken | Westwood | |||
| 9/20/19 Fri | 7:30 | St. John’s | Oceanside Collegiate | |||
| 9/20/19 Fri | 7:30 | Sumter | Northwestern | |||
| 9/20/19 Fri | 7:30 | Timberland | Bishop England | |||
| 9/20/19 Fri | 7:30 | Union | Greer | |||
| 9/20/19 Fri | 7:30 | Wade Hampton (H) | Barnwell | |||
| 9/20/19 Fri | 7:30 | Wade Hampton (G) | Laurens | |||
| 9/20/19 Fri | 7:30 | Ware Shoals | Camden Military | |||
| 9/20/19 Fri | 7:30 | West Ashley | Wando | |||
| 9/20/19 Fri | 7:30 | West-Oak | St. Joseph’s | |||
| 9/20/19 Fri | 7:30 | White Knoll | Gray Collegiate | |||
| 9/20/19 Fri | 7:30 | Whitmire | Branchville | |||
| 9/20/19 Fri | 7:30 | Wren | Clinton | |||
